Unplanned surgical excisions of soft tissue sarcomas (“whoops operations”) can complicate the subsequent multidisciplinary management of the primary tumor due to potential microscopic tumor seeding of prior surgical sites, violation of uninvolved anatomic compartments, and sometimes a lack of gross residual tumor on staging imaging. Valerie Grignol, MD and Kilian Salerno, MD join John M. Kane III, MD, Vice-Chair of the SSO Sarcoma Disease Site Work Group, to discuss how unplanned excisions might alter the surgical and radiation decision-making for the treatment of soft tissue sarcomas.