During this episode of SurgOnc Today, Dr. Alexander Parikh, Chair of the SSO HPB DSWG, is joined by Dr. Ana Gleissner from the University of Colorado Anschutz Medical Campus in Aurora, CO and Dr. Shimul Shah from the University of Cincinnati College of Medicine in Cincinnati, OH. They review the role of liver transplantation for malignancies of and to the liver. In this second installment of the two-part series, they discuss the role of liver transplantation in the treatment of colorectal liver metastases including the impact of liver-directed therapies on the role of liver transplant.