During this episode of SurgOnc Today®, Kenneth Cardona, MD, Nicholas Tawa, MD, PhD, Elizabeth Davis, MD, and Marwan Moussa, MD, discuss the value and role of cryoablation in the management of patients with desmoid tumors and examine clinical scenarios in which this treatment modality should be offered. They also discuss the CRYODESMO-1 prospective trial which investigated the utility of cryoablation in desmoid tumors.